With regards to enzyme action, this statement is incorrect

The correct option is: "addition of a lot of succinates does not reverse the inhibition of succinic dehydrogenase by malonate"

Explanation:
To understand why this statement is incorrect (making it the correct choice for this question), we must analyze the mechanism of competitive inhibition using the classic example of the enzyme succinate dehydrogenase.

1. Competitive Inhibition Concept:
In competitive inhibition, the inhibitor closely resembles the chemical structure of the substrate. As a result, both the substrate (succinate) and the inhibitor (malonate) compete for binding to the same active site of the enzyme (succinate dehydrogenase).

2. Reversibility of Competitive Inhibition:
Because the substrate and inhibitor compete for the exact same active site, the inhibition is fully reversible. If we increase the concentration of the substrate (succinate) significantly, the substrate molecules will outnumber the inhibitor molecules (malonate). Consequently, the probability of the substrate binding to the active site increases dramatically, thereby reversing the inhibitory effect of malonate.

3. Evaluating the Statements:
• "Malonate is a competitive inhibitor of succinic dehydrogenase" is a correct biological fact.
• "the substrate binds with the enzyme at its active site" is a correct general principle of enzyme action.
• "the non-competitve inhibitor binds the enzyme at a site distinct from that binding the substrate" is a correct definition of non-competitive inhibition.
• Therefore, the statement "addition of a lot of succinates does not reverse the inhibition of succinic dehydrogenase by malonate" is scientifically incorrect because adding an excess of substrate (succinate) does reverse the competitive inhibition caused by malonate.