Which of the following is a type of autosomal recessive genetic disorder?

The correct option is Sickle cell anaemia.

Understanding Autosomal Recessive Disorders:
An autosomal recessive genetic disorder is a condition caused by a mutation in a gene located on one of the autosomes (non-sex chromosomes). For an individual to manifest the disorder, they must inherit two copies of the mutated gene—one from each parent. Individuals who inherit only one mutated allele are carriers and typically do not show symptoms of the disease.

Why Sickle Cell Anaemia is the Correct Answer:
Sickle cell anaemia is a classic example of an autosomal recessive disorder. It is caused by a point mutation in the HBB gene located on autosome chromosome 11, which encodes the β-globin polypeptide chain of haemoglobin. A child will only develop sickle cell anaemia if they inherit the mutated haemoglobin allele (HbS) from both parents (homozygous genotype HbS HbS). If they inherit one normal allele (HbA) and one mutated allele (HbS), they are carriers of the sickle cell trait but do not develop the disease.

Analyzing the Other Options:
• Haemophilia: This is an X-linked recessive disorder, meaning the defective gene is located on the X chromosome (a sex chromosome) rather than an autosome.
• Skeletal dysplasia: This refers to a diverse group of bone and cartilage growth disorders. Many common forms, such as achondroplasia, are inherited in an autosomal dominant pattern rather than an autosomal recessive pattern.