Trade name of genetically engineered insulin is

The correct option is Humilin.

Step-by-step Explanation:

1. Understanding Genetically Engineered Insulin:
Insulin is a hormone produced by the pancreas that regulates glucose levels in the blood. For people with diabetes, external insulin administration is necessary. Traditionally, insulin was extracted from the pancreases of slaughtered pigs and cows, which often caused allergic reactions in humans due to slight structural differences.

2. The Recombinant DNA Breakthrough:
To overcome these limitations, scientists used recombinant DNA technology to produce human-identical insulin. By inserting the human insulin gene sequence into the DNA of the bacterium Escherichia coli (E. coli), the bacteria could be cultured to produce large quantities of human insulin chains (Chain A and Chain B), which were then chemically combined by disulfide bonds to form active insulin.

3. Trade Name:
In 1978, the biotechnology company Genentech, in partnership with Eli Lilly and Company, successfully produced this genetically engineered insulin. Eli Lilly marketed this product under the trade name Humulin (a portmanteau of "Human Insulin"). It became the first-ever approved genetically engineered drug for human use in 1982.