Question Details

This condition is necessary for a cell to qualify through the G2 checkpoint

Options

A

Cell should be of a size sufficient enough

B

Complete and accurate DNA replication

C

Sufficient stockpile of nucleotides

D

Complete attachment of mitotic spindle fibers to kinetochores

Correct Answer :

Complete and accurate DNA replication

Solution :

The correct option is: "Complete and accurate DNA replication".

Explanation:
The cell cycle contains several critical regulatory checkpoints that monitor and verify whether the processes at each phase have been accurately completed before progressing to the next phase. The G2 checkpoint (also known as the G2/M checkpoint) is the control point that transitions the cell from the G2 phase into the mitotic (M) phase.

The primary function of the G2 checkpoint is to ensure genomic integrity. Specifically, it assesses whether:
1. The DNA has been completely and accurately replicated during the preceding Synthesis (S) phase.
2. Any damaged DNA is repaired before mitosis begins.

If DNA replication is incomplete or if there is DNA damage, the cell cycle is arrested at this checkpoint to allow time for repair or completion. If the damage is irreparable, the cell may undergo programmed cell death (apoptosis). This prevention of damaged or incomplete DNA from being segregated to daughter cells is vital for preventing mutations and genomic instability. Therefore, complete and accurate DNA replication is a necessary condition to pass the G2 checkpoint.

Analyzing the other choices:
- "Cell should be of a size sufficient enough" is a requirement monitored primarily at the G1 checkpoint (and to some extent G2), but it is not the defining criterion for the G2 checkpoint compared to genomic integrity.
- "Sufficient stockpile of nucleotides" is crucial prior to entering the S phase (assessed at the G1 checkpoint) to ensure DNA replication can occur, not at the G2 checkpoint.
- "Complete attachment of mitotic spindle fibers to kinetochores" is the condition assessed at the M checkpoint (spindle checkpoint) during metaphase, not the G2 checkpoint.

Unlock Our Free Library

Access expert-curated educational resources and study materials—completely free.