The statement which is incorrect with respect to enzyme action is

Options :

1. the substrate binds with the enzyme as its active site

2. a non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate

3. Addition of a lot of succinates does not reverse the inhibition of succinic dehydrogenase by malonate

4. malonate is a competitive inhibitor of succinic dehydrogenase