The antibody dependent cytotoxicity is seen in

The correct option is Non-compatible-blood transfusion.

Antibody-Dependent Cellular Cytotoxicity (ADCC), along with complement-mediated lysis, is a hallmark mechanism of Type II (cytotoxic) hypersensitivity reactions. In Type II hypersensitivity, antibodies (primarily IgG or IgM) bind to antigens on the surface of specific target cells. Once coated with antibodies, these cells are targeted for destruction by immune cells such as Natural Killer (NK) cells, macrophages, or neutrophils via ADCC, or they are lysed through the complement system.

Let us break down why the correct option is the right answer and analyze the other choices:
1. Non-compatible-blood transfusion: When a person receives mismatched or non-compatible blood, their pre-existing antibodies (such as anti-A or anti-B antibodies) bind to the foreign antigens on the donor's red blood cells. This antigen-antibody binding on the cell surface initiates Type II hypersensitivity mechanisms, including complement-mediated destruction and antibody-dependent cytotoxicity, leading to intravascular hemolysis. Therefore, ADCC is directly involved in this reaction.
2. Generalised anaphylaxis & Local anaphylaxis: Both of these represent Type I (immediate) hypersensitivity reactions. These reactions are mediated by IgE antibodies binding to mast cells and basophils, triggering degranulation and the release of vasoactive amines (like histamine). ADCC does not play a role in Type I hypersensitivity.
3. Immune complex reaction: This represents a Type III hypersensitivity reaction. It involves the deposition of soluble antigen-antibody (immune) complexes in tissues, which leads to complement activation and neutrophil recruitment, causing localized tissue damage (e.g., Arthus reaction, serum sickness). Unlike Type II hypersensitivity, it is not directed against antigens fixed on cell surfaces and does not primarily proceed via cellular cytotoxicity targeted at specific cells.