Schuffner’s dots are related to

The correct option/answer is RBC of man.

Step-by-Step Explanation:

1. What are Schüffner’s dots?
Schüffner's dots (also known as Schüffner's stippling) refer to a distinctive morphological change observed under a microscope in red blood cells (erythrocytes) infected by certain species of the malaria parasite, primarily Plasmodium vivax and Plasmodium ovale.

2. How do they appear?
When blood smears from an infected individual are stained with Romanowsky stains (such as Giemsa or Leishman stain), these dots appear as multiple, tiny, uniform, pinkish-to-red granules or stippling distributed throughout the cytoplasm of the host cell.

3. Biological Significance:
These dots represent invaginations of the erythrocyte membrane (caveola-vesicle complexes) created by the parasite to import nutrients and transport its own proteins. Since the host organism infected by these malaria parasites is human, these alterations are specifically visualized within the RBC of man (human red blood cells).

4. Evaluating the Options:
- Entamoeba histolytica: This is a protozoan parasite causing amoebiasis and does not form Schüffner's dots.
- Leucocytes of frog: Schüffner's dots are specific to red blood cells infected with human malaria, not frog white blood cells.
- RBC of man: This is correct because Schüffner's dots are pathological features identified within human red blood cells infected by Plasmodium vivax/ovale.
- Epithelium of stomach of mosquito: While the malaria parasite undergoes part of its life cycle (oocyst formation) in the mosquito stomach wall, Schüffner's dots are not found there; they are strictly associated with the erythrocytic stage in human red blood cells.