Question Details

Persons with ‘AB’ blood group are called as “Universal recipients”. This is due to :

Options

A

Absence of antigens A and B on the surface of RBCs

B

Absence of antigens A and B in plasma

C

Presence of antibodies, anti-A and anti-B, on RBCs

D

Absence of antibodies, anti-A and anti-B, in plasma

Correct Answer :

Absence of antibodies, anti-A and anti-B, in plasma

Solution :

The correct option is: Absence of antibodies, anti-A and anti-B, in plasma.

To understand why individuals with the AB blood group are known as "universal recipients," we need to look at the composition of the ABO blood grouping system. Blood types are determined by the presence or absence of specific proteins called antigens on the surface of red blood cells (RBCs) and corresponding proteins called antibodies circulating in the blood plasma.

In the ABO system:
- Blood Group A: Has antigen A on RBCs and anti-B antibodies in the plasma.
- Blood Group B: Has antigen B on RBCs and anti-A antibodies in the plasma.
- Blood Group O: Has no antigens on RBCs but has both anti-A and anti-B antibodies in the plasma.
- Blood Group AB: Has both antigen A and antigen B on the surface of RBCs, but has neither anti-A nor anti-B antibodies in the plasma.

During a blood transfusion, the recipient's immune system will attack transfused red blood cells if the recipient's plasma contains antibodies against the antigens on the donor's RBCs. Because individuals with blood group AB completely lack anti-A and anti-B antibodies in their plasma, their immune system will not recognize or destroy transfused red blood cells from any blood group (A, B, AB, or O). Consequently, they can safely receive blood from any donor, making them "universal recipients."

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