In tissues, amoebiasis is treated with

The correct option is "Any of these".

Amoebiasis is an infectious disease caused by the protozoan parasite Entamoeba histolytica. When the infection spreads beyond the intestinal lumen into tissues (such as the intestinal wall or the liver, causing amoebic liver abscess), tissue amoebicides are used for treatment.

Here is a step-by-step explanation of why all three listed medications are effective for treating tissue amoebiasis:
1. Metronidazole: This is the gold standard and most commonly used nitroimidazole derivative. It is highly effective against Entamoeba histolytica in the tissues (intestinal wall and liver abscess) because it is rapidly absorbed and reaches high concentrations in these organs.
2. Tinidazole: This is a second-generation nitroimidazole that behaves similarly to metronidazole but has a longer half-life, allowing for shorter treatment courses with comparable or superior efficacy in treating invasive tissue amoebiasis.
3. Nitazoxanide: This is a broad-spectrum thiazolide antiparasitic agent. It is converted to its active metabolite, tizoxanide, which inhibits the pyruvate:ferredoxin oxidoreductase enzyme pathway in the parasite. It has documented efficacy against both intestinal and tissue-invasive forms of amoebiasis.

Since Metronidazole, Tinidazole, and Nitazoxanide are all clinically indicated and effective for treating tissue-invasive amoebiasis, the correct choice is "Any of these".