Duchenne muscular dystrophy can be cured with

The correct option is None of these.

Duchenne muscular dystrophy (DMD) is a severe, progressive, X-linked recessive genetic disorder characterized by rapid muscle degeneration and weakness. It is caused by mutations in the DMD gene, which is responsible for producing the protein dystrophin. Dystrophin acts as a vital structural link, maintaining the integrity of muscle cell membranes during contraction. Without functional dystrophin, muscle fibers experience ongoing mechanical stress, leading to cellular damage, inflammation, and eventual replacement of muscle tissue with fibrotic and fatty tissue.

Currently, there is no definitive cure for Duchenne muscular dystrophy. While various treatments are employed to manage symptoms, improve quality of life, and slow disease progression, none of them can restore normal dystrophin production or reverse the muscle degeneration permanently:
1. Corticosteroids (such as prednisone or deflazacort) are the standard pharmacological therapy used to reduce inflammation and temporarily prolong muscle strength and function, but they are not a cure.
2. Allopurinol (a medication primarily used to treat gout by lowering uric acid levels) has no therapeutic or curative role in DMD.
3. Creatinine phosphokinase inhibitors are not a clinical treatment for curing DMD; creatinine phosphokinase (CPK) is merely a biomarker that leaks into the blood due to muscle damage, and inhibiting it does not address the underlying genetic lack of dystrophin.

Because none of the listed options or any current medical treatments can cure Duchenne muscular dystrophy, the correct choice is None of these.